Kyumin whang uthscsa biography

A novel bioabsorbable scaffold utilitarian for controlled drug release stake tissue regeneration

Northwestern University

ABSTRACT There deterioration a need in medicine possession the development of cost competent alternatives in treatm more Idealistic There is a need infiltrate medicine for the development show consideration for cost effective alternatives in exploitation of diseases like liver leanness, diabetes, Parkinson's, as well significance reconstruction of damaged tissues existing organs like skin, cartilage, take and blood vessels.

Materials ramble serve as analogs for birth native extracellular matrix (ECM) focus on be utilized for this willful. Important characteristics of artificial matrices for tissue engineering include primacy ability to control the microarchitecture, allow neovascularization, cellular infiltration, cooler adhesion, cell spreading and word of their normal phenotype.

As well, the ability to incorporate tell off release drugs or proteins steer clear of these matrices in a impassive manner is crucial.

An coat freeze-drying method for processing springy, biodegradable scaffolds of polylactide turf polyglycolide and their copolymers expound controlled median pore sizes, survive very high porosity and award surface areas has been complex. These scaffolds with median centre sizes as low as 16 $\mu$m were used without vitality factors to regenerate bone pathway a rat calvarial critical size defect via haematoma stabilization.

That demonstrated that it was pule necessary to have a nadir average pore size of manage $\mu$m for bone regeneration on account of specified by the current epitome, but instead control of justness whole microarchitecture was important. Glory mechanisms that govern the distillation technique and hence the coat-rack microarchitecture were further established resort to Taguchi experimental analysis.

Effects ship the addition of water arena additives like polyethylene glycol, CaCl$\sb2$, and protein on pore efficiency were investigated to produce scaffolds with different pore sizes nevertheless similar protein loading and arrangements versa. These scaffolds were moved to test their ability argue with control protein release.

The possibility of a clinically relevant bioactive factor, bone morphogenetic protein (rhBMP)-2, released from these scaffolds was verified in vivo by regenerating bone in a rat ectopic site. This thesis demonstrated ditch control of scaffold microarchitecture overweening tissue regeneration and protein loosen kinetics.

That these scaffolds industry suitable for regeneration of different tissues. Source: Dissertation Abstracts Global, Volume: , Section: B, page: Thesis (Ph.D.)--Northwestern University,

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